Why Hyalgan

A solid 30-year record of experience worldwide 4,5

  • Approximately 50 million injections of HYALGAN® have been administered worldwide 4
  • Well-established safety profile
  • Local treatment with no known drug interactions 2,3
Hyalgan box and needle

When to use HYALGAN®

Use early in the disease process 3,15

  • Proven results for patients with mild to moderate OA (Kellgren grade 2 or 3) 3
  • Can be used concurrently with COX-2 inhibitors or NSAIDs 3
  • May reduce patient use of NSAIDs 15

How to use HYALGAN®

HYALGAN® is administered by intra-articular injection. A treatment cycle consists of 5 injections, 1 injection per week for 5 weeks. Some patients may experience benefit with 3 injections*.

* Some patients may experience benefit with 3 injections given at weekly intervals (one injection per week for three weeks). This has been noted in studies reported in the literature in which patients treated with 3 injections were followed for 60 days.


Do not concomitantly use disinfectants containing quaternary ammonium salts* for skin preparation because hyaluronic acid can precipitate in their presence.

* The following products may contain quaternary ammonium salts: water repellents, fungicides, emulsifiers, paper softeners, antistatic agents, and corrosion inhibitors. For example, Benzalkonium Chloride.


  • Do not use HYALGAN® if the package is opened or damaged. Store in the original packaging (protected from light) below 77°F (25°C). DO NOT FREEZE.
  • Strict aseptic administration technique must be followed.
  • Remove joint effusion fluid, if present, before injection of HYALGAN®. Do not use the same syringe for removing joint effusion fluid and for injecting HYALGAN®. Take care to remove the tip cap of the syringe and needle aseptically. Inject HYALGAN® into the joint through a 20-gauge needle.
  • The syringe/vial is intended for single use. The contents of the syringe/vial must be used immediately once the container has been opened. Discard any unused HYALGAN®. Inject the full 2 mL in one knee only. If treatment is bilateral, a separate syringe/vial should be used for each knee. 14