OA synovial fluid with higher HA concentration — improves viscosity 10
shock-absorbing, lubricating ability of depleted synovial fluid 11
The synthesis of hyaluronan within synovial joints may be influenced by the concentration and molecular weight of hyaluronan in the extracellular environment.
HYALGAN® is a viscous solution with a molecular weight (500,000-730,000 daltons) fraction of purified natural sodium hyaluronate in buffered physiological sodium chloride, having a pH of 6.8-7.5. The sodium hyaluronate is extracted from rooster combs. Hyaluronate (also known as hyaluronan or HA) is a natural complex sugar of the glycosaminoglycan family and is a long-chain polymer containing repeating disaccharide units of Na-glucuronate-N-acetylglucosamine. 14
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