What to expect with your HYALGAN® treatment

HYALGAN® injections give you long-lasting relief of osteoarthritis knee pain

  • HYALGAN® can provide long-lasting pain relief for up to 6 months
  • HYALGAN® can be safely used for up to 30 months

HYALGAN® is a safe choice

HYALGAN® is not a drug. Its principal component is a naturally derived substance called hyaluronan that relieves your pain by lubricating and cushioning your knee joint. Hyaluronan is a natural chemical found in the body and is present in a particularly high amount in joint tissues and in the fluid that fills the joint (also called synovial fluid). HYALGAN® is injected directly into the knee.

HYALGAN® injections work differently than oral pain medications. HYALGAN® does not pass through your bloodstream to work. Because HYALGAN® is injected directly into your knee, it does not cause stomach bleeding problems like some pain medications.

  • HYALGAN® does not interfere with any other medicines you may be taking for osteoarthritis or other conditions
  • HYALGAN® has been shown to be safe for repeat treatment in a 30-month study

HYALGAN® has been safely used for 24 years worldwide. Approximately 38 million injections have been given.

Important Safety Information

HYALGAN is contraindicated in patients with known hypersensitivity to hyaluronate preparations. Intra-articular injections are contraindicated in cases of present infections or skin diseases in the area of the injection site to reduce the potential for developing septic arthritis.

Transient increases in inflammation in the injected knee following HYALGAN injection have been reported in some patients with inflammatory arthritis such as rheumatoid arthritis or gouty arthritis. Physicians should evaluate whether HYALGAN treatment should be initiated when objective signs of inflammation are present.

The effectiveness of a single treatment cycle of less than 3 injections has not been established.

Patients should be advised to avoid any strenuous or prolonged weight-bearing activities within 48 hours following intra-articular injection.

Use caution when injecting HYALGAN into patients who are allergic to avian proteins, feathers and egg products.

Joint effusion, if present, should be removed prior to injection.

The safety and effectiveness of HYALGAN has not been established in children or in pregnant or lactating women. It is unknown whether HYALGAN is excreted in human milk.

In the US clinical trial of 495 patients, the only adverse event showing statistical significance vs placebo was injection-site pain. Other adverse events included gastrointestinal complaints, headache, local ecchymosis and rash, local joint pain and swelling, and local pruritus. However, the incidence of these events was similar in the HYALGAN-treated and placebo groups. In other clinical studies, the frequency and severity of adverse events occurring during repeat treatment cycles did not increase over that reported for a single treatment cycle.

Indication

HYALGAN is indicated for the treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative nonpharmacologic therapy and to simple analgesics, eg, acetaminophen.

You are about to leave this Web site.

Fidia Pharma USA does not review the information contained on this Web site and/or database for content, accuracy, or completeness. Use of and access to this information is subject to the terms, limitations, and conditions set by the Web site and/or database producer.

Fidia Pharma USA makes no representation as to the accuracy or any other aspect of the information contained on such Web site and/or database, nor does Fidia Pharma USA necessarily endorse such Web site and/or database.

Click the "CONTINUE" button below to go to the page you requested, or the "CANCEL" button to return to the previous page.