What is HYALGAN®?

HYALGAN® is a solution that contains a natural substance called hyaluronate. Hyaluronate is normally found in the fluid that lubricates and cushions your knee joint. HYALGAN® is injected into your knee to relieve pain.

HYALGAN® is a treatment option for people who do not get adequate pain relief from simple painkillers (like Tylenol® or Advil®) or from exercise and physical therapy. HYALGAN® injections can be used in addition to prescription pain relievers (like Celebrex®).

HYALGAN® is injected directly into your knee by your health care provider.

  • HYALGAN® is a 5-injection regimen given at weekly intervals that provides long-lasting pain relief for up to 6 months
  • Some patients get benefits with 3 injections given at weekly intervals*
*

Some patients may experience benefit with 3 HYALGAN® injections given at weekly intervals. This has been noted in studies of
patients receiving 3 injections who were followed for 60 days.

Individual results may vary but HYALGAN® has shown to relieve knee pain for up to 6 months.

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Important Safety Information

HYALGAN is contraindicated in patients with known hypersensitivity to hyaluronate preparations. Intra-articular injections are contraindicated in cases of present infections or skin diseases in the area of the injection site to reduce the potential for developing septic arthritis.

Transient increases in inflammation in the injected knee following HYALGAN injection have been reported in some patients with inflammatory arthritis such as rheumatoid arthritis or gouty arthritis. Physicians should evaluate whether HYALGAN treatment should be initiated when objective signs of inflammation are present.

The effectiveness of a single treatment cycle of less than 3 injections has not been established.

Patients should be advised to avoid any strenuous or prolonged weight-bearing activities within 48 hours following intra-articular injection.

Use caution when injecting HYALGAN into patients who are allergic to avian proteins, feathers and egg products.

Joint effusion, if present, should be removed prior to injection.

The safety and effectiveness of HYALGAN has not been established in children or in pregnant or lactating women. It is unknown whether HYALGAN is excreted in human milk.

In the US clinical trial of 495 patients, the only adverse event showing statistical significance vs placebo was injection-site pain. Other adverse events included gastrointestinal complaints, headache, local ecchymosis and rash, local joint pain and swelling, and local pruritus. However, the incidence of these events was similar in the HYALGAN-treated and placebo groups. In other clinical studies, the frequency and severity of adverse events occurring during repeat treatment cycles did not increase over that reported for a single treatment cycle.

Indication

HYALGAN is indicated for the treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative nonpharmacologic therapy and to simple analgesics, eg, acetaminophen.

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