*Some patients may experience benefit with 3 injections given at weekly intervals;
this benefit has been noted in studies reported in the literature in which patients
treated with 3 injections were followed for 60 days.10
For osteoarthritis knee pain
3 for 3 efficacy
HYALGAN® has demonstrated 3 injection efficacy in 3 placebo controlled clinical trials.*8,30-31
Proven pain relief with 3 injections10,11
Pain relief at day 60:
HYALGAN® 3-injection regimen vs placebo
|
|
Adapted from Carrabba M et al. P<.05 vs saline control.
†As measured using a 100-mm VAS.11
Study design
Six-month, double-blind, placebo- and arthrocentesis-controlled trial; patients
(N=100) were randomized into 5 groups (saline-control weekly X 5, plus arthrocentesis
at baseline; arthrocentesis weekly X 5; IA HYALGAN® 20 mg weekly X 1, plus arthrocentesis
weekly X 5; IA HYALGAN® 20 mg weekly X 3, plus arthrocentesis at baseline and days
21 and 28; IA HYALGAN® 20 mg weekly X 5, plus arthrocentesis at baseline).11
For osteoarthritis knee pain
Proven again—pain relief with 3 injections10,12
Pain relief at day 60:
HYALGAN® 3-injection regimen vs placebo
|
|
Adapted from Bragantini A et al.
‡As measured using a 100-mm VAS.12
Study design
Placebo-controlled, single-blind parallel study (N=55) comparing 20 mg HYALGAN®
weekly X 3, 40 mg HYALGAN® weekly X 3, and 2 mL saline weekly X 3.12
For osteoarthritis knee pain
Proven again—pain relief with 3 injections10,13
Pain relief at day 60:
HYALGAN® 3-injection regimen vs placebo
|
|
Adapted from Grecomoro G et al.
§As measured using a 100-mm VAS.13
Study design
Randomized, placebo-controlled, double-blind study (N=34 patients; 40 joints) comparing
20 mg HYALGAN® weekly X 3 and placebo (phosphate buffer) weekly X 3.13
*Some patients may experience benefit with 3 injections given at weekly intervals;
this benefit has been noted in studies reported in the literature in which patients
treated with 3 injections were followed for 60 days.10