Six-month, double-blind, placebo-controlled, US multicenter study (N=495) of patients aged ≥ 40 years with Kellgren grade 2 or 3 osteoarthritis of the knee. The study compared intra-articular (IA) HYALGAN® 20 mg/wk X 5 with IA saline and 500 mg bid naproxen groups. All patients were allowed up to 4,000 mg/d for rescue analgesia as needed for pain.⁸

Long-lasting pain relief as effective as daily naproxen

One 5-injection cycle of HYALGAN® provided 6 months of pain relief equivalent to 364 doses of naproxen (500 mg bid), with fewer adverse events⁸
HYALGAN® is the only hyaluronan with comparative registration data vs NSAID therapy¹⁰^,^30-31

Important Safety Information for HYALGAN®

HYALGAN® is indicated for the treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative nonpha-rmacologic therapy, and to simple analgesics, eg, acetaminophen
HYALGAN® is contraindicated in patients with known hypersensitivity to hyaluronate preparations. Intra-articular injections are contraindicated in cases of past and present infections or skin diseases in the area of the injection site
The effectiveness of a single treatment cycle of less than 3 injections has not been established
In the US clinical trial of 495 patients, the only adverse event showing statistical significance vs placebo was injection-site pain
Other adverse events included gastrointestinal complaints, headache, local ecchymosis and rash, local joint pain and swelling, and local pruritus. However, the incidence of these events was similar in the HYALGAN®-treated and placebo groups
In other clinical studies, the frequency and severity of adverse events occurring during repeat treatment cycles did not increase over that reported for a single treatment cycle

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Proven Pain Relief

Pain relief that goes on8

2 out of 3 patients reported pain relief each month for 6 months8

Long-lasting pain relief as effective as daily naproxen

Pain relief that goes on⁸

2 out of 3 patients reported pain relief each month for 6 months⁸