HYALGAN® demonstrated significant pain relief with a 5-injection regimen vs placebo in the largest pivotal controlled hyaluronate study conducted in the US (N=495) among patients with OA of the knee.⁸

67% reduction in mean pain severity from baseline
68% of patients reported significant pain relief at 6 months (P=.013 vs saline control)⁸

HYALGAN®has demonstrated 3 injection efficacy in 3 placebo controlled clinical trials.

*Some patients may experience benefit with 3 HYALGAN® injections given at weekly intervals. This has been noted in studies of patients receiving 3 injections who were followed for 60 days.¹⁰

HYALGAN® is the only hyaluronan proven safe and effective for repeat use in a 30-month study²⁵

Incremental improvement in pain relief with repeat cycles²⁵

Important Safety Information for HYALGAN®

HYALGAN® is indicated for the treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative nonpha-rmacologic therapy, and to simple analgesics, eg, acetaminophen
HYALGAN® is contraindicated in patients with known hypersensitivity to hyaluronate preparations. Intra-articular injections are contraindicated in cases of past and present infections or skin diseases in the area of the injection site
The effectiveness of a single treatment cycle of less than 3 injections has not been established
In the US clinical trial of 495 patients, the only adverse event showing statistical significance vs placebo was injection-site pain
Other adverse events included gastrointestinal complaints, headache, local ecchymosis and rash, local joint pain and swelling, and local pruritus. However, the incidence of these events was similar in the HYALGAN®-treated and placebo groups
In other clinical studies, the frequency and severity of adverse events occurring during repeat treatment cycles did not increase over that reported for a single treatment cycle

Click here for additional important information for HYALGAN®.

HYALGAN® Efficacy Data

Largest US study shows proven pain relief

HYALGAN®has demonstrated 3 injection efficacy in 3 placebo controlled clinical trials.

HYALGAN® is the only hyaluronan proven safe and effective for repeat use in a 30-month study25

HYALGAN® is the only hyaluronan proven safe and effective for repeat use in a 30-month study²⁵