A 3-injection cycle of HYALGAN®* provided significantly better pain relief than a 3-injection cycle of an intra-articular corticosteroid (6-MPA)^† at 60 days (P<.05)^14,36

Superior pain relief versus intra-articular (IA) corticosteroid line graph

Adapted from Leardini, et al.

Study design

Open-label, parallel, randomized, controlled trial (N=40) comparing HYALGAN® 20 mg/wk X 3 with 6-methylprednisolone acetate (steroid) 40 mg/wk X 3.¹⁴

Following treatment with HYALGAN®

Patients experienced pain relief that persisted or improved at days 35 and 60

*Some patients may experience benefit with 3 HYALGAN® injections given at weekly intervals. This has been noted in studies of patients receiving 3 injections who were followed for 60 days¹⁰

^† 6-MPA=6-methylprednisolone acetate.

^‡ Mean spontaneous pain score during normal daily living activities recorded on a 100-mm VAS.

Important Safety Information for HYALGAN®

HYALGAN® is indicated for the treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative nonpha-rmacologic therapy, and to simple analgesics, eg, acetaminophen
HYALGAN® is contraindicated in patients with known hypersensitivity to hyaluronate preparations. Intra-articular injections are contraindicated in cases of past and present infections or skin diseases in the area of the injection site
The effectiveness of a single treatment cycle of less than 3 injections has not been established
In the US clinical trial of 495 patients, the only adverse event showing statistical significance vs placebo was injection-site pain
Other adverse events included gastrointestinal complaints, headache, local ecchymosis and rash, local joint pain and swelling, and local pruritus. However, the incidence of these events was similar in the HYALGAN®-treated and placebo groups
In other clinical studies, the frequency and severity of adverse events occurring during repeat treatment cycles did not increase over that reported for a single treatment cycle

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