Another alternative is to treat the pain of osteoarthritis of the knee with hyaluronate injections. Hyaluronate is a natural substance found in high amounts in the synovial fluid of normal, healthy joints. When injected into a knee with OA, hyaluronate acts like a lubricant and shock absorber.²¹ Several different hyaluronate products are available for medical use, including HYALGAN®.

Surgery

Knee surgery may be an option for people who cannot obtain relief of knee pain in a less invasive mannner.¹⁹

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HYALGAN® facts
HYALGAN® clinical trials

Important Safety Information for HYALGAN®

HYALGAN® is indicated for the treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative nonpha-rmacologic therapy, and to simple analgesics, eg, acetaminophen
HYALGAN® is contraindicated in patients with known hypersensitivity to hyaluronate preparations. Intra-articular injections are contraindicated in cases of past and present infections or skin diseases in the area of the injection site
The effectiveness of a single treatment cycle of less than 3 injections has not been established
In the US clinical trial of 495 patients, the only adverse event showing statistical significance vs placebo was injection-site pain
Other adverse events included gastrointestinal complaints, headache, local ecchymosis and rash, local joint pain and swelling, and local pruritus. However, the incidence of these events was similar in the HYALGAN®-treated and placebo groups
In other clinical studies, the frequency and severity of adverse events occurring during repeat treatment cycles did not increase over that reported for a single treatment cycle

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